Healing Potential of Mesenchymal Stem Cells Cultured on a Collagen-Based Scaffold for Skin Regeneration

healing potential of mesenchymal stem cells cultured on a collagen-based scaffold for skin regeneration

background: wound healing of burned skin remains a major goal in public health. previous reports showed that the bone marrow stem cells were potent in keratinization and vascularization of full thickness skin wounds. methods: in this study, mesenchymal stem cells were derived from rat adipose tissues and characterized by flowcytometry. staining methods were used to evaluate their differentiatio...

Healing potential of mesenchymal stem cells cultured on a collagen-based scaffold for skin regeneration.

BACKGROUND Wound healing of burned skin remains a major goal in public health. Previous reports showed that the bone marrow stem cells were potent in keratinization and vascularization of full thickness skin wounds. METHODS In this study, mesenchymal stem cells were derived from rat adipose tissues and characterized by flowcytometry. Staining methods were used to evaluate their differentiatio...

A fine structure study on osteogenesis of mesenchymal stem cells cultured with a 3D collagen scaffold

We cultured human bone-derived mesenchymal stem cell(MSC)s (HMS0014:Yub621b) on a 3D collagen gel scaffold (Cellmatrix Type I-A) under non-inducing and inducing conditions in vitro. Conventional transmission electron microscopy (TEM) was performed for studying turnover of the MSCs and extracellular matrix (ECM) scaffold. The non-induced MSCs were fibroblast-like cells containing a variable numb...

Healing potential of stem cells for diabetic ulcers

A wound is described as any laceration in normal anatomic structure and functional integrity of the skin. Chronic wounds don’t progress through the normal wound healing process in 3 months leaving open laceration of different degrees of severity. Diabetic wound healing is an insurmountable process due to the chronic nature of diabetic wounds. For these complications, this has been a challenge i...

Cytotoxicity of Chitosan Derived from Shrimp for Bone Scaffold on Adipose Tissue-Derived Mesenchymal Stem Cells

the role of mesenchymal stem cells in skin wound healing

mesenchymal stem cells (mscs) could differentiate into various types of tissues. these cells serve as a backup for the regeneration and repair of tissues or cells after injury. a skin wound is defined as an injury to the skin that needs to be restored. all types of cells in skin especially mesenchymal stem cells play important role in wound healing process. in particular, paracrine signaling of...